![HEDRON_Logo_White_2021](https://www.globusmedical.com/hedron/wp-content/uploads/sites/3/2023/02/HEDRON_Logo_White_2021.png)
THE FACE OF FUSION
ACDF | ALIF | LLIF | PLIF | TLIF
HEDRON® 3D printed titanium interbody spacers feature a biomimetic porous scaffold designed to promote bone formation onto and through the implant.
![](http://www.globusmedical.com/hedron/wp-content/uploads/sites/3/2019/11/partner-trabecular-bone-inspired-design-r2.png)
![](http://www.globusmedical.com/hedron/wp-content/uploads/sites/3/2020/02/partner-encourage-cellular-response-r3.png)
![](http://www.globusmedical.com/hedron/wp-content/uploads/sites/3/2020/02/partner-stimulate-bone-growth-r3.png)
TRABECULAR BONE
INSPIRED DESIGN
Osseointegration between an implant and surrounding bone may help achieve stability. HEDRON® integrates biomimetic architecture with characteristics of established interbody fusion devices.
![bone001r2](https://www.globusmedical.com/hedron/wp-content/uploads/sites/3/2020/02/bone001r2.png)
MicroCT of trabecular bone
![bone002r2](https://www.globusmedical.com/hedron/wp-content/uploads/sites/3/2020/02/bone002r2.png)
SEM image of HEDRON®
![bone003](https://www.globusmedical.com/hedron/wp-content/uploads/sites/3/2019/11/bone003.png)
Clear visualization
Supplemental fixation required.
FEATURES
Lattice stiffness comparable to trabecular bone1
70% porosity
Expansive pore size distribution
Roughened surface texture
1. Mechanical study data on file.
Strength and Porosity
Unlike first generation 3D printed implants (grid and open architecture), HEDRON® strikes the ideal balance of strength and porosity through a sturdy frame and pore size distribution similar to trabecular bone.
![repeating-icon-1024x818r2](https://www.globusmedical.com/hedron/wp-content/uploads/sites/3/2020/02/repeating-icon-1024x818r2-1024x818.png)
Grid
![open-architecture-iconR2](https://www.globusmedical.com/hedron/wp-content/uploads/sites/3/2020/02/open-architecture-iconR2-1024x818.png)
Open architecture
![HEADRON-icon-1024x818r2](https://www.globusmedical.com/hedron/wp-content/uploads/sites/3/2020/02/HEADRON-icon-1024x818r2-1024x818.png)
HEDRON®
![pore-size-graph-r3](https://www.globusmedical.com/hedron/wp-content/uploads/sites/3/2020/02/pore-size-graph-r3.png)
![circle1r1](https://www.globusmedical.com/hedron/wp-content/uploads/sites/3/2019/11/circle1r1.png)
ONGROWTH
<300μm
Small pores (<300μm) are recommended to support initial surface adhesion2
![circle2r1](https://www.globusmedical.com/hedron/wp-content/uploads/sites/3/2019/11/circle2r1.png)
BONE FORMATION
>300μm
Large pores (>300μm) have been shown to lead to direct osteogenesis3
2. Torres-Sanchez et al. Material Science and Engineering. 2017 Mar; 219–228.
3. KKarageorgiou V, Kaplan D. Biomaterials. 2005;26(27):5474-91.
ENCOURAGES CELLULAR
RESPONSE
In Vitro testing demonstrated that HEDRON® generated a greater expression of Vascular Endothelial Growth Factor (VEGF) and Osteocalcin, two biological indicators of bone formation when seeded with osteoblasts.4
![OsteocalcinGeneExpression](https://www.globusmedical.com/hedron/wp-content/uploads/sites/3/2023/02/OsteocalcinGeneExpression.png)
![VascularEndothelialGrowthFactor](https://www.globusmedical.com/hedron/wp-content/uploads/sites/3/2023/02/VascularEndothelialGrowthFactor.png)
SEM images of cell proliferation at 21 days (500x magnification)
![peek_circleR2](https://www.globusmedical.com/hedron/wp-content/uploads/sites/3/2020/02/peek_circleR2.png)
PEEK
![tav_circleR2](https://www.globusmedical.com/hedron/wp-content/uploads/sites/3/2020/02/tav_circleR2.png)
TAV
![hedron_circle](https://www.globusmedical.com/hedron/wp-content/uploads/sites/3/2019/11/hedron_circle.png)
HEDRON®
4. Cell study data on file.
PROMOTES BONE
FORMATION
Unlike PEEK and TAV, the porous architecture of HEDRON® allows for bone to grow through the spacer walls and incorporate into the fusion mass. In a pre-clinical ovine study, HEDRON® implants showed significantly more bone growth compared to PEEK and titanium implants at 6-weeks post-op.5
![peek](https://www.globusmedical.com/hedron/wp-content/uploads/sites/3/2022/07/peek.png)
![Implant](https://www.globusmedical.com/hedron/wp-content/uploads/sites/3/2023/02/Implant.png)
![titanium](https://www.globusmedical.com/hedron/wp-content/uploads/sites/3/2022/07/titanium.png)
A pre-clinical sheep interbody study using HEDRON®, Titanium (Ti), and PEEK implants was performed to compare bone ingrowth and ongrowth.
![AtLeast51%](https://www.globusmedical.com/hedron/wp-content/uploads/sites/3/2023/02/AtLeast51.png)
![AtLeast175%](https://www.globusmedical.com/hedron/wp-content/uploads/sites/3/2023/02/AtLeast175.png)
5. Animal study data on file.
*p<0.05 vs PEEK.
†p<0.05 vs TAV
Accommodates Multiple Approaches and Techniques
Procedure | HEDRON® Spacer | Footprint | Heights | Lordosis |
ACDF | ![]() HEDRON C® |
12x14, 14x16, 15x18mm | 5, 6, 7, 8, 9, 10, 11, 12mm | 0°, 7°, 12°, 15°, 20° |
![]() HEDRON IC® |
12x14, 14x16, 15x18mm | 5, 6, 7, 8, 9, 10, 11, 12mm | 0°, 7°, 12° | |
ALIF | ![]() HEDRON A® |
22x29, 24x35, 28x39mm | 9, 11, 13, 15, 17, 19, 21mm | 8°, 15°, and 20° |
![]() HEDRON IA® |
24x30, 26x34, 29x39mm | 11, 13, 15, 17, 19, 21mm | 8°, 15°, 20°, 25°, and 30° | |
LLIF | ![]() HEDRON L® |
18, 22mm widths 40–60mm heights | 7, 9, 11, 13, 15mm | 10°, 15° |
PLIF | ![]() HEDRON P® |
8x22, 10x22, 10x26, 10x30, 12x26, 12x30mm | 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17mm | 8°, 15° |
TLIF | ![]() HEDRON T® |
10x28, 11x33mm | 7, 8, 9, 10, 11, 12, 13, 15, 17mm | 8°, 15° |